In Acton, Oregon, sisters Alex, Stevie, and Joey take turns telling about their lives, including their long line of actor ancestors, creative family dinners, toe marshmallows, swearing in Shakespeare, and the Sisters Club.

Judy is excited about becoming a doctor, especially when Class 3T starts a new unit on the human body, but she learns more about being a patient when she catches tonsillitis from her little brother, Stink.

A class visit to the Gross-Me-Out exhibit at the science museum inspires Stink Moody to create a variety of terrible smells to put on the sneakers he plans to enter in the World's Worst Super-Stinky Sneaker contest.

As Judy and the rest of the Virginia Dare Bookworms prepare for the Book Quiz Blowout competition against second- and third-grade readers, her team discovers the other group has a fourth-grader and worry about their chance of winning sets in.

When Judy Moody gets serious about protecting the environment, her little brother Stink thinks she is overdoing it, but she manages to inspire her third grade class to undertake an award-winning, environment-saving project.

"Look up! Look out! A comet is coming, a comet is coming! Stink is camped out in the backyard with his sister, Judy, and he can't wait to lay eyes on P/2015 OZ4, also known as the Sherman-Holm Comet. But then news of an asteroid hitting Russia reaches Stink, and suddenly he's feeling squeamish (and squash-ish) about close encounters of the outer-space kind. Will donning an aluminum-foil cape and building a bunker in the basement help keep him safe?...

After learning about the American Revolution on a family trip to Boston, Massachusetts, Judy Moody makes her own Declaration of Independence and tries to prove that she is responsible enough to have more freedoms, such as a higher allowance and her own bathroom.

Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to give away his favorite, Astro.