Having changed the course of human history after unwittingly wondering what could be worse than going to prison, George and Harold are shot through time back to kindergarten, where they are subjected to bullying and a clueless school principal.

After Principal Krupp forbids George and Harold from continuing to create comics about feces, the boys begin a story about Rip Van Tinkle, a man who transforms into a puddle of urine and begins to destroy all of the toilets in town.

Dog Man has been working hard to overcome his bad habits, but when his obsessions turn to fears, he finds himself the target of an all-new supervillain, while Petey the Cat, who was just released from jail, starts a new life with Li'l Petey.

General Jackrabbit and his Robo-Rabbits from Jupiter attempt to take over the world on Ricky Ricotta's birthday.

Evil Uncle Unicorn attempts to dominate earth by using a Ladybot to trick Mighty Robot.

A mouse named Ricky Ricotta and his giant flying robot attempt to save the world from an invasion of massive mutant mosquitoes from Mercury.

All the other dogs make fun of Oscar the dachshund until one Hallowneen when, dressed as a hot dog, Oscar bravely rescues the others.

George, Harold, Captain Underpants, and Sulu the Bionic Hamster battle the three Ridiculous Robo-Boogers in an attempt to turn the Bionic Booger Boy back into Melvin Sneedly.

Ricky the mouse and his robot get sent to bed without TV, which saves them from falling under a strange spell. When Victor Von Vulture, a villain from Venus, invades Earth, only Ricky and his robot can send him soaring back into space.

"Excitement and imagination run wild as Naomi, Melvin, Poppy, Gilbert, Curly, and their siblings get back to making comics with originality and laughter. But wait--have they cleaned their rooms yet?! After their chores, the rambunctious group presents even more amazing mini-comics. By working together, the baby frogs discover that small things can have a huge impact"--