A snotty situation ensues when Melvin Sneedley, an academically-gifted student, turns into the Bionic Booger Boy and must be stopped by George, Harold, and Captain Underpants. By flipping the pages, the reader may view animated illustrations.

Having changed the course of human history after unwittingly wondering what could be worse than going to prison, George and Harold are shot through time back to kindergarten, where they are subjected to bullying and a clueless school principal.

George and Harold, and their doubles, Yesterday George and Yesterday Harold, have a good thing going. Two of them go to school, while the other two hide in the tree house and play video games all day-then they switch! But when their malicious gym teacher, Mr Meaner, creates a method of mind control that turns their fellow students into attentive, obedient, perfect children, the future of all humanity will be in their hands!

When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.