The past looms threateningly for Sasha Jensen's horizon. She does not trust the future, even as she knows she must move into it. When she is picked up by a young man, she begins to feel that she is still capable of desires and emotions.

When Victoria Cruz wakes up in the psychiatric ward of a Texas hospital after her failed suicide attempt, she still has no desire to live, but as the weeks pass, and she meets Dr. Desai and three of the other patients, she begins to reflect on the reasons why she feels like a loser compared with the rest of her family.

Mary Beth Latham puts everything else aside in order to focus on her one son who suffers from severe depression, but she is not prepared for the violence that follows.