Skye Fargo heads for Oregon's Willamette Valley at the behest of timber baron Luther Brunsdale, whose lucrative lumber business is being threatened by the Phantoms, a tribe of mysterious killers who have managed to remain invisible to their pursuers.

The Gold Rush boomtown of Ophis, California, is plagued by a series of robberies, extortion schemes, and murders, and with no sheriff in town to keep the peace, things can only get worse, until the Trailsman arrives.

While escorting the lovely Lara Newton to see her brother, a soldier in Texas Indian country, Skye Fargo finds himself caught in the middle between a desperate Native American tribe and U.S. Cavalry thirsting for blood.

Skye Fargo rescues a half-dead man in the desert who is on the run from the law. He returns the fugitive to town, only to find that the accused murderer he brought back alive is sure to be lynched, even though he may be innocent.